# 17950 S US Highway 281, San Antonio, TX 78221

> **TL;DR:** other, $4,000,000. Est. $21,393/mo.

## Property at a Glance

| Attribute | Value |
|-----------|-------|
| Price | $4,000,000 |
| Lot Size | 6,490,440 sqft (149.00 acres) |
| Property Type | Other (Other) |
| Status | Active |
| Days on Market | 0 |

## Estimated Monthly Costs

| Category | Amount |
|----------|--------|
| Principal & Interest (20% down, 30-year at 6.5%) | $20,226 |
| Estimated Insurance | $1,167 |
| **Total** | **$21,393** |

## Property Highlights

- 149.00 acre lot

## Description

### Agent Description
MEDINA RIVER FRONTAGE !! 149 Acres for sale outside of the city limits. Seller is willing to subdivide5 to 10 acre tracts. Located in San Antonio, TX off of Highway 281 S. This area is home to Navistar Manufacturing, Mission del Lago Golf Course, San Antonio Missions National Historic Park and Trailheads. South San Antonio is also home to Toyota Motor Manufacturing and Texas A&M University at San Antonio. Close proximity to both Loops 410 and 1604. Possible uses: Industrial, Residential Development, Commercial, Agricultural, Investment or Personal Use.

## Location

- **Address:** 17950 S US Highway 281, San Antonio, TX 78221
- **County:** Bexar

## Listing Agent

- **Name:** Audrey Galo
- **Brokerage:** Ashton Galo Realty
- **Broker Phone:** (210) 268-8367

## Photos

![17950 S US Highway 281 - Photo 1](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f2287894350r.jpg)

![17950 S US Highway 281 - Photo 2](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f1046270734r.jpg)

![17950 S US Highway 281 - Photo 3](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f3634890301r.jpg)

![17950 S US Highway 281 - Photo 4](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f3485146559r.jpg)

![17950 S US Highway 281 - Photo 5](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f2591231353r.jpg)

![17950 S US Highway 281 - Photo 6](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f3979020268r.jpg)

![17950 S US Highway 281 - Photo 7](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f2542283765r.jpg)

![17950 S US Highway 281 - Photo 8](http://lh.rdcpix.com/69e3e8897c26cc1b131a13acfb64bb30l-f344078451r.jpg)

---

**MLS#:** 1634414 | **Updated:** 2026-10-22
**Source:** listhub

*Copyright © 2026 LERA MLS. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.*

[View on PropertySimple](https://staging.propertysimple.ai/listing/17950-s-us-highway-281-san-antonio-tx-78221-cf2d3c697f224f69a6d63d5ff477bf97)

---

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