# 221 N Main Street, Hannibal, MO 63401

> **TL;DR:** commercial, $305,000 ($49/sqft), built 1860, 6,216 sqft. Est. $1,322/mo.

## Property at a Glance

| Attribute | Value |
|-----------|-------|
| Price | $305,000 |
| Price/sqft | $49 |
| Square Feet | 6,216 |
| Year Built | 1860 |
| Lot Size | 2,570 sqft (0.06 acres) |
| Property Type | Commercial (Retail) |
| Status | For Sale |
| Days on Market | 0 |

## Estimated Monthly Costs

| Category | Amount |
|----------|--------|
| Mortgage (20% down, 6.5%) | $1,322 |
| **Total** | **$1,322** |

## Property Highlights

- Built in 1860
- 0.06 acre lot

## Description

### Agent Description
WELL BELOW APPRAISED VALUE!!!    Excellent Opportunity to own your own building in Historic Downtown Hannibal. North Main Street attracts visitors and locals to shops, restaurants, and most of all the Mark Twain Boyhood Home and Museum properties. 221 North Main has had a substantial rehab around 2010. Storefront restoration, new mechanical systems, roofing, interior remake, and lighting. Second floor has potential for additional retail square footage. 3 HVAC units, side entry off Bird Street and includes two private concrete parking pads. Over 4000 square feet of finished space. Be apart of Hannibal's tourist community. Location: Downtown, High Traffic, Retail Center

## Location

- **Address:** 221 N Main Street, Hannibal, MO 63401
- **County:** Marion
- **Neighborhood:** City/Hannibal
- **Coordinates:** 39.711123, -91.356854
- **Google Maps:** https://www.google.com/maps?q=39.711123,-91.356854

## Listing Agent

- **Name:** Sue-ann Westhoff
- **Brokerage:** Prestige Realty, Inc
- **Phone:** 5738227884
- **Email:** sue-ann.westhoff@prestigerealty.net

## Primary Photo

![221 N Main Street - Primary Photo](http://lh.rdcpix.com/c60b56d889910b83f0a86437b8a61265l-f409514894r.jpg)

*25 total photos available on [listing page](https://www.propertysimple.com/listing/221-n-main-street-hannibal-mo-63401-25018821)*

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**MLS#:** 25018821 | **Updated:** 2026-04-24
**Source:** listhub

*Copyright © 2026 Mid America Regional Information Systems, Inc. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.*

[View on PropertySimple](https://www.propertysimple.com/listing/221-n-main-street-hannibal-mo-63401-25018821)

---

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